An Integrated Approach to Process Development
Our services in Catalysis and Enabling Technology are differentiated through our integrated approach in the overall process development. We develop efficient catalytic reactions and reaction processes by utilizing the newest tools together with verified experimental techniques, scientific and industrial knowledge.
- Custom development planning (early development vs. manufacturing process or fit for purpose vs. optimized for efficiency).
- High-Throughput Catalyst screening of pressurized, non-pressurized reactions and air sensitive reactions.
- High-Throughput Synthesis of air sensitive reactions.
- Increased reaction performance through mechanistic understanding, utilizing various experimental and computational techniques.
- Lead identification using High-Throughput DoE experimentation.
- Process optimization and robustness with Kinetic-DoE.
- Green chemistry: Chemistry in water, flow chemistry, base metal catalysis.
- Evaluation and development of batch, semi-batch and flow processes.
- Scale-up under best engineering consideration and representative scalable procedures.
- Reaction Safety: Gas evolution and heat of reaction.
- Efficient technology transfer
Integrated Catalysis & Enabling Technology Advantages
- Flexibility based on needs – utilization of HTE to evaluate solvent/base combinations)
- Speed – finding suitable catalysts and reaction conditions quicker with access to one of the world’s largest commercial catalyst libraries
- Experts and generalists – big picture solutions with expert knowledge
- Efficiency – using the best phase appropriate tool
- Knowledge retention – our PhDs utilize their experience across different technologies, platforms and projectss
Catalysis & Enabling Technology Services
- We offer all of our services as a standalone service or integral with our other services (Synthesis, process development, GMP manufacturing and crystallization).
- Development planning: We provide an individualized work proposal that suits the needs of the customer (early development vs. manufacturing process or fit for purpose vs. optimized for efficiency).
- Scouting and Screening: We support the early development for route selection utilizing our High-Throughput platform.
- Synthesis: Supporting early drug development by synthesizing API libraries (96 well)
- Optimization: We optimize reactions using various tools, which can encompass our High-Throughput platform in combination with DoE, kinetic DoE, Bayesian optimization and improving catalyst performance through mechanistic understanding.
- Operational evaluation: Evaluate a specific reaction for batch, semi-batch and flow operation.
- Process stability: Identification of best operational procedures, stable holding points and most stable operating range.
- Scale-up: The reaction is being scaled-up under best engineering consideration and representative scalable procedures considering mixing and mass-transfer.
- Reaction Safety: Isocratic reaction calorimetry, adiabatic temperature rise calculation, gas evolution measurement.
- Efficient technology transfer: Throughout the collaboration the results are frequently communicated in written reports and through teleconferences. A final report can be issued summarizing all relevant information in an updated context of the final development stage.
Cross-Functional Support for Phase-Appropriate Development
A comprehensive development of efficient processes involves all of the above steps. Depending on the needs, we also offer these services separately for phase appropriate development and in conjunction with J-STAR’s other functional groups.
Cross-functional support:
- High-Throughput Screening of reactions
- Statistical and DoE support for NOR/PAR of reactions and crystallization processes
- In-situ reaction monitoring
- Support for pressurized reactions
- Reaction Safety Studies.
- Computational chemistry for 1H-NMR, IR spectra, thermodynamic properties.
- Continuous flow for highly reactive intermediates and for safe operations.
Equipment
Capabilities
