Enabling Technology I. Co-Precipitation Technology (CPT) for the Enhancement of Flowability and Bulk Density
Co-processing-Co-Precipitation-Technology-CPT-for-the-Enhancement-of-Flowability-and-Bulk-Density.pdf – 868.18 KB
Co-processing-Co-Precipitation-Technology-CPT-for-the-Enhancement-of-Flowability-and-Bulk-Density.pdf – 868.18 KB
Direct compression (DC) process is the preferred method for tablet production because it is both simple and energy saving. However, only a minority of active pharmaceutical ingredients (APIs) can be made into tablets by using DC because of the powder properties of most APIs which have low bulk density, low flowability, etc. (1); Hence, technologies need to be developed to improve these powder properties to make the production of tablets feasible through DC. The co-precipitation technology (CPT) described below has been proven and can be used for the enhancement of powder flowability and bulk density.